Music about prostaglandins

The song Oklahoma! has inspired Dr. Ahern to create a music about prostaglandins... :)

http://www.mediafire.com/?c3n25wp37xorw31

Prostaglandins

Prossss-taglandins
The ei-co-sa-noids creating pain
Are the ones to blame - when you get inflamed
And ouch(!) - they hurt inside your brain

Prossss-taglandins
Every throb and ache gets magnified
If you hope to win, cyclo-oxygen's
Generation's got to be denied

The Vioxx has all been recalled
So go get yourself Tylenol-ed
And if you aaaaaaaaaaaaache
Blame PGH synthaaaaaaaaase!

We must complain that
You make the aches prostaglandins
Prostaglandin - D2, F1, G2, E2
Prostaglandin, it's you
.

Music about NAD+

Here it is another music made by Dr. Kevin Ahern, this time inspired in the song Penny Lane, from The Beatles.

http://www.mediafire.com/?vpz29j3x3996ws5

N-A-D

In the catabolic pathways that our cells employ
Oxidations help create the ATP
While they lower Gibbs free energy
Thanks to enthalpy

If a substrate is converted from an alcohol
To an aldehyde or ketone it is clear
Those electrons do not disappear
They just rearrange – very strange

N-A-D is in my ears and in my eyes
Help-ing mol-e-cules get oxidized
Mak-ing N-A-D-H then

And the latter is a problem anaerobically
‘Cause accumulations of it muscles hate
They respond by using pyruvate
To produce lactate

Catalyzing is necessity for cells to live
So the enzymes grab their substrates eagerly
If they bind with high affinity
Low Km you see – just trust me

N-A-D is in my ears and in my eyes
Help-ing mol-e-cules get oxidized
Mak-ing N-A-D-H then
.

Music about proteins

Here it is one more music from Dr. Kevin Ahern, this time about proteins. It was based on the Oh Little Town of Bethlehem.

http://www.mediafire.com/?hr9d8wj1501brqn

Oh Little Protein Molecule

Instructor sings
Oh little protein molecule
You're lovely and serene
With twenty zwitterions like
Cysteine and alanine

Everyone sings
Your secondary structure
Has pitches and repeats
Arranged in alpha helices
And beta pleated sheets

Instructor sings
The Ramachandran plots are
Predictions made to try
To tell the structures you can have
For angles phi and psi

Everyone sings
And tertiary structure
Gives polypeptides zing
Because of magic that occurs
In protein fol-ding

Instructor sings
A folded enzyme's active
And starts to catalyze
When activators bind into
The allosteric sites

Everyone sings
Some other mechanisms
Control the enzyme rates
By regulating synthesis
And placement of phosphates

Instructor sings
And all the regulation
That's found inside of cells
Reminds the students learning it
Of pathways straight from hell

Everyone sings
So here's how to remember
The phosphate strategies
They turn the GPb's to a's
And GSa's to b's
.

Atomic music

Did you know that each atom produces music while suffers radioactive decay? What if suddenly we became atomic musicians, using the atoms as musical instruments? Believe it or not, there is actually people working on it. You can check the information in the following link:

http://www.physics.org/featuredetail.asp?id=63

If you want to try your skills as atomic musicion, you can do it here:

http://www.physics.org/explorelink.asp?id=5342

P.S. - Thanks for the link, Alves!

Music about the thermodynamics of metabolism

The song Yesterday, from The Beatles, was used to create a music about the thermodynamics of the cellular metabolism. Here it is the final result...

http://www.mediafire.com/?2fqq9en6ujrktbn

The Cell's Lament

Instructor sings
Woe is me
My substrates are losing entropy
Causing gains in Gibbs free energy
Oh I can't lose no en - tro- py

Re-a-lly
I could use a source of enthalpy
To combat the rise in Delta G
Oh I believe in enthalpy


Everyone sings
I crave en-er-gy
Don't you see?
It's getting worse

My re-actions all
Soon will stall
And then rever-r-r-se

Instructor sings
ATP
It's the metabolic currency
Guess I'll spend a bit judiciously
To help reduce the Delta G
Help reduce the Delta G

Music about biochemistry (2)

Here it goes another song about biochemistry, this time with the interesting name Brain farts. :) It was adapted from the Raindrops Keep Fallin' On My Head.

http://www.mediafire.com/?2zsrhqcgs2gkg2u

Brain Farts Just Happen In My Head
Brain farts just happen in my head
I think it might be due to something Kevin said
Bi-o-che-mis-try
Gets brain farts a poppin' in my head and they're poppin'
So I just wiped out the teardrops from my eyes
And told my brain it had to do some men-tal exer-cise
Burn some ATP
So brain farts can stop inside my head they'll be stoppin'
'Cause there's one thing I've learned
When energy increases it sure pleases
My mental state - I'm doing great as tension eases
Now brain farts don't happen in my head
So I'm sure the final will be easier instead
Cyclic AMP
Stops brain farts from poppin' in my head they're not poppin'
Thanks to caffeine
Nothin's worryin' me

Music about biochemistry

Here it goes one more Christmas song (Oh Christmas tree) that was used to make a different song, this time about Biochemistry.

http://www.mediafire.com/?l2z36319b2evc3g

Biochemistry/Biochemistry

Biochemistry Biochemistry
I wish that I were wiser
I feel I'm in way o'er my head
I need a new advisor

My courses really shouldn't be
Such metabolic misery
Biochemistry Biochemistry
I wish that I were wiser

Biochemistry Biochemistry
Reactions make me shiver
They're in my heart and in my lungs
They're even in my liver

I promise I would not complain
If I could store them in my brain
Biochemistry Biochemistry
I wish that I were wiser

Biochemistry Biochemistry
I'm truly in a panic
Your mechanisms murder me
I should have learned organic

For all I have to memorize
I ought to win the Nobel Prize.
Biochemistry Biochemistry
I wish that I were wiser

Music about DNA

Is there anyone who does not know the music YMCA? Here it is a version of it about DNA... :)

http://www.mediafire.com/?v0lk6tqayxgjpcb

B-DNA

Phosphates

Are in nucleotides

I say phosphates

Cover bases inside

I say phosphates

Span the 5 and 3 primes

There's no need - to - be - all - mixed - up

Bases

Carry info you see

I say bases

Are all complement'ry

I say bases

Like A,T,G and C

They have got - to - be – all - paired - up

It's fun to play with some

B-DNA

It's got a boatload of

G-C-T-A

It's got everything

A polymerase needs

When you melt all the A's and T's

It's fun to play with some

B-DNA

It's got a boatload of

G-C-T-A

You can make RNAs

With a po-ly-mer-ase

Just by pairing up U's with A's

Proteins

Full of amino A's

I say proteins

Come from mRNAs

I say proteins

Require tRNAs

There is more – you - need - to – trans-late

Codons

Like our friend U-A-C

I say codons

Come in clusters of three

I say codons

Have one base wobble –ee

Now you can - go - forth - and - tran-slate

It's fun to play with some

B-DNA

It's got a boatload of

G-C-T-A

All those hydrogen Bs

And right-hand he-li-ces

Anti-par-a-llel fives and threes

It's fun to play with some

B-DNA

It's got a boatload of

G-C-T-A

All those hydrogen Bs

And right-hand he-li-ces

Anti-par-a-llel fives and threes

It's fun to play with some

B-DNA

It's got a boatload of

G-C-T-A

All those hydrogen Bs

And right-hand he-li-ces

Anti-par-a-llel fives and threes

Music about fermentation (2)

This is one more Christmas song (Rudolph the Red-Nosed Reindeer) that turned out into a song about biochemistry, this time about fermentation.

http://www.mediafire.com/?5afx4u8ed6uk80l

The Alcohol Song

Cells go through fermentation

When they’re out of NAD
Substrate phosphorylation’s
How they make their ATP

Cells are efficient makers ( . . .of)

Energy on which to live
With no electron takers
They need an alternative

Oh glycolysis would stop

Without NAD
Isn’t fermentation great?
For reducing pyruvate!

And if you might be thinking

“Man this isn’t cool at all”
Ask yourself when you’re drinking
“Where do we get alcohol?”

Music about hemoglobin

Christmas is becoming near and a well known Christmas song (Santa Claus is Coming to Town) was adapted to describe the way hemoglobin works.

http://www.mediafire.com/?2e445u61ttc6j2w

Hemoglobin's Moving Around
Oh isn't it great
What proteins can do
Especially ones that bind to O

Hemoglobin's moving around

Inside of the lungs

It picks up the bait
And changes itself from T to R state
Hemoglobin's moving around

The proto-porphyrin system

Its iron makes such a scene
Arising when an O binds
Pulling up on histidine

The binding occurs
Cooperatively
Thanks to changes qua-ter-nar-y
Hemoglobin's moving around

It exits the lungs
Engorged with O

In search of a working body tissue

Hemoglobin's moving around

The proton concentration
Is high and has a role
Between the alpha betas
It finds imidazole

To empty their loads

The globins decree
"We need to bind 2,3BPG"
Hemoglobin's moving around

The stage is thus set
For grabbing a few
Cellular dumps of CO

Hemoglobin's moving around

And then inside the lungs it
Discovers ox-y-gen
And dumps the CO off

To start all o'er agin

So see how this works
You better expect
To have to describe the Bohr effect
Hemoglobin's moving around

Video about functional groups (2)

Music about functional groups

Music about protein translation (2)

The music Maria from West Side Story has inspired the creation of a music about protein translation.

http://www.mediafire.com/?cmjxncd61cpflra

Translation

Translation

The most intricate thing I ever saw

From five prime to three prime, translation, translation

The final step that we know about the central dog-ma

Amino, carboxyl, translation, translation. . . .

Translation, translation, translation . .

Translation!

I just learned the steps of translation

And all the things they say

About tRNA

Are true

Translation!

To form peptide bonds in translation

The ribosomal cleft

Must bind to an E-F

tee-you!

Translation!

A-U-G binds the f-met's cargo

16S lines up Shine and Dalgarno

Translation

I'll never stop needing translation

The most intricate thing I ever saw

Translationnnnnnnnnnnnnnnnnn

Music about enzyme catalysis

This music is about enzyme catalysis and is an adaptation of the song Close to You.

http://www.mediafire.com/?omzv9utktseeodu

Catalyze
My enzymes
Truly are inclined
To convert
Things they bind
Turn the key
Covalently
Cat-a-lyze
 

How do cells

Regulate these roles?
Allo-ster-ic controls
Two forms, see
States R and T
Mod-u-late
 
Competing inhibition keeps
The substrates from the active site
They raise Km, but leave Vmax and shirk
While the non-competers bind elsewhere
And lift the plot made on Lineweaver-Burk

Other ways
Enzymes can be blocked
When things bind
Then get locked
Stuck not free
Tied to the key
Su-i-cide

Penicillin’s action stops
Peptidoglycan cross-links in
Bacterial cell walls in awesome ways
Beta lactam ring’s reactive site
Starts bonding with D-D-transpeptidase
 
So there are
Several enzyme states
Counteract-ing substrates
Now you see
Blocking the key
Regulates
 
Cat-a-lysts
Have to be controlled
Some get slowed
Put on hold
It's sublime
How the enzymes
(slow) Cat-a-lyze
 
ahhhhhhhhhhhhhhhhhhh - cat-a-lyzeahhhhhhhhhhhhhhhhhhh - cata-
lyzeahhhhhhhhhhhhhhhhhhh - cat-a-lyze

Musica about cellular respiration (2)

Music about the fatty acids

This music is about the roles of fatty acids in our cells and is based in the song Halls of Montezuma.

http://www.mediafire.com/?2exx92e6264493c

Fatty Acids in Our Cells

From the fatty acids in our cells

To the lipids in our brains

We are made of biochemicals

Built in metabolic chains

Using glycolytic ATP

And electron energy

We can synthesize most everything

With the help of Delta G

A cell will tend to pump out sodium

But potassium it imports

It accomplishes this magic with

ATPase antiports

Our bilayer lipid membranes

Protect the cells' insides

Partly made of sphingolipids

We know as gangliosides

When it comes to regulation

The little cell has got it made

It phosphorylates a lot of things

With its own kinase cascade

Stimulated at a hormone site

Metabolic yang and yin

That's turned on by epinephrine

And turned off by insulin

Music about fermentation

I like very much this music... :)
It is about fermentation and is based in the famous Oh Susannah!

Here it is the link to download it:
http://www.mediafire.com/?zhbfbz91u70ca10

Oh, late last night I went to jog

when everything was still

I came upon a gravel road

a-windin’ up the hill

I don’t know why I did it but

I played a game with death

Ran up that hill in double time

And held in all my breath

Fermentation!

I need some NAD+

my cells are lackin’ oxygen

But using ATP

‘bout half way up I felt the burn

My hip down to my knee

if only I had stayed awake

In biochemistry

then I’d have had a warning, but

regrets were just too late

I stood in pain - my body was

reducing pyruvate!

Fermentation!

I need some NAD+

my cells are lackin’ oxygen

But using ATP

Well up came my professor who

was trailin’ close behind

he told me how fermenting was

a process most unkind

Oh ATP is energy

It’s keeping you alive

It’s mostly made by protons mov- ing

through the complex five

Fermentation!

I need some NAD+

my cells are lackin’ oxygen

But using ATP

In making ATP a pro- ton gradient is key

to ADP’s phosphoryla- tion, oxidatively

Electrons pass through complex four

And oxygen, you know

picks up four more electrons and

Fermentation!

I need some NAD+

my cells are lackin’ oxygen

But using ATP

I hope that you can clearly see

Exactly what I meant

That oxygen is needed for

The proton gra-di-ent

your muscles work in overdrive

And use up ATP

you might be breathin’ hard but lack sufficient energy

Fermentation!

I need some NAD+

my cells are lackin’ oxygen

But using ATP

You’re in a heap o’ trouble and

this breath may be your last

if you can’t make some ATP

and NAD+ real fast

It’s lactate dehydrogenase

To save the day, you see

Turn pyruvate to lactate and

Produce more NAD+!

Fermentation!

I need some NAD+

my cells are lackin’ oxygen

But using ATP

The NAD+’s important,

Are You gettin’ all of this?

it gets fed back into the pathway

of glycolysis”

It hit my ear, it was so clear

and all made sense to me

Although I had no oxygen

I still made ATP

Fermentation!

I need some NAD+

my cells are lackin’ oxygen

But using ATP

For all he’d done I took my prof

to sit down for a drink

admitting that his lesson earlier

had made me think

I took a swig of ale

And grinning wide, I said with glee

Oh, fermentation hurts but all in all

It’s fine by me

Fermentation!

I need some NAD+

my cells are lackin’ oxygen

But using ATPmakes double H2O

Fermentation!

Video about the Krebs cycle (2)

Here it goes one more video about the Krebs cycle, this time in a karaoke version. :)

Music about enzymes

Here it goes a link to download another Metabolic Melody, this time about enzymes. It was base on the song Downtown.

http://www.mediafire.com/?w0gd96oo6ecpymg

Enzymes

Reactions alone

Energy peaks

Are what an enzyme defeats

In its catalysis

Enzymes

Transition state

Is what an enzyme does great

And you should all know this

Enzymes

Catalytic action won't run wild - don't get hysteric

Cells can throttle pathways with an enzyme allosteric

You know it's true

So when an effector fits

It will just rearrange

all the sub-u-nits

Inside an

ENZYME!

Flipping from R to T

ENZYME!

Slow catalytically

ENZYME!

No change in Delta G

(Enzyme, enzyme)

You should relax

When seeking out the Vmax though

There are many steps

Enzymes

Lineweaver Burk

Can save a scientist work

With just two intercepts

Enzymes

Plotting all the data from kinetic exploration

Let's you match a line into a best fitting equation

Here's what you do

Both axes are inverted then

You can determine Vmax and

Establish Km for your ENZYMES!

Sterically holding tight

ENZYMES!

Substrates positioned right

ENZYMES!

Inside the active site

Enzymes (Enzymes, enzymes, enzymes)

Could starve your cells to the bone

Thank God we all produce

Enzymes

Units arrange

To make the chemicals change

Because you always use

Enzymes

Sometimes mechanisms run like they are at the races

Witness the Kcat of the carbonic anhydrases

How do they work?

Inside of the active site

It just grabs onto a substrate

and squeezes it tight

In an

ENZYME!

CAT-al-y-sis

In an ENZYME!

V versus S

In an

ENZYME!

All of this working for you

(Enzyme, enzyme)
 

Video about the respiratory chain

Hey Soul Sister is a very well known song. Its biochemical version is not so famous...